I have been on Depo for 7 years (I'm 25). I had what I would consider mild acne while on the Depo. I recently stopped the Depo (about 4 months ago) and I have never had acne this bad!!! I'm praying that it calms down once my hormones get back to normal. It's definitely no fun! I have Proactiv and it definitely helps to get rid of the redness and calms things down a little - good makeup covers the rest. Good luck!