Google is so - amazing Posted: Apr 28th, 2016 - 6:09 pm In Reply to: ESL: pathology for ______________ specimen. sm - Terri
from http://home.ccr.cancer.gov/LOP/intranet/PolicyManual/SpecimenCollection/specimenhand.asp
Specimen: any product of a medical procedure. These can be soft tissues, boney tissue; fluids, foreign bodies, surgical appliances/hardware. The terms “sample”, “specimen”, and “tissue” are often used interchangeably.
Fixative: a solution used to stabilize cellular components in preparation for histological examination. Proper fixation is essential for histology, but it kills cells and acts in other ways that limits many research applications. 10% neutral buffered formalin is the most common routine fixative.
Fresh: no fixative has been used. Fresh tissue samples must be frozen, placed in a transport media to keep the cells alive, or stabilized in some other way as soon as possible to prevent autolysis.
Frozens: specimens that are or have been frozen for rapid microscopic exam during an interoperative consultation. Frozen section slides are cut on a cryostat for rapid microscopic analysis. The remaining tissue is placed in fixative to be made into permanents.
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PERMANENT: specimen that have been treated with fixative and processed to a paraffin matrix that permanently preserves them at ambient temperature. “Paraffin block” is an equivalent term. “Permanents”, or paraffin blocks, are specimen for which a microscopic histological exam can be performed. The histology of permanents is superior to that of frozens.
Gross only examination: a descriptive exam of the macroscopic features of the specimen that does not include a microscopic exam. Specimens for “gross only” are usually foreign bodies or otherwise not practical to be made into permanents.
Procure: the process of allocating portions of the specimen to fulfill the research protocol requirements while preserving representative portions for clinical diagnosis.
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